What is the NO dosage range for patients receiving nitric oxide therapy?

• A. 1 to 10 ppm
• B. 10 to 20 ppm
• C. 20 to 80 ppm
• D. 100 to 200 ppm

Answer: (C)

Inhaled nitric oxide is delivered as a gas in parts per million and acts as a selective pulmonary vasodilator to lower pulmonary vascular resistance in neonatal patients with conditions like PPHN. The typical therapeutic range is 20 to 80 ppm. Clinically, you would start around 20 ppm and adjust up to higher levels (within that range) only as needed based on response and safety. Dosing below this range is usually subtherapeutic for producing meaningful vasodilation, while doses above 80 ppm are not recommended because they increase the risk of adverse effects such as methemoglobinemia and formation of nitrogen dioxide. Continuous monitoring of methemoglobin levels and NO2 is essential during therapy, and wean as the patient improves.