A sweat chloride test is considered abnormal when the chloride level is above

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Multiple Choice

A sweat chloride test is considered abnormal when the chloride level is above

Explanation:
The key idea is the threshold used to define an abnormal sweat chloride result in cystic fibrosis. In CF, defective CFTR function leads to high chloride in sweat because chloride reabsorption in the sweat ducts is reduced. Clinically, sweat chloride values are interpreted as: typically less than 40 mmol/L is normal, 40–59 mmol/L is indeterminate, and 60 mmol/L or higher is abnormal and supportive of CF in the right clinical context. So the level at which the result is considered abnormal is 60 mmol/L (or higher). An extremely high value like 80 would also be abnormal, but 60 is the established cutoff.

The key idea is the threshold used to define an abnormal sweat chloride result in cystic fibrosis. In CF, defective CFTR function leads to high chloride in sweat because chloride reabsorption in the sweat ducts is reduced. Clinically, sweat chloride values are interpreted as: typically less than 40 mmol/L is normal, 40–59 mmol/L is indeterminate, and 60 mmol/L or higher is abnormal and supportive of CF in the right clinical context. So the level at which the result is considered abnormal is 60 mmol/L (or higher). An extremely high value like 80 would also be abnormal, but 60 is the established cutoff.

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